Monday, October 2, 2017

Memorial Sloan Kettering Works to Improve Cancer Detection


Based in New York City, Timothy (Tim) Maleck maintains a well-established presence as a financial analyst. A member of the Delta Sigma Pi co-ed professional business fraternity, Timothy Maleck also participates in fundraising events for cancer such as Relay for Life and Cycle for Survival. 

Established a decade ago, Cycle for Survival has a unique focus on rare cancers and has raised more than $140 million toward more than 100 research projects and clinical trials undertaken by the Memorial Sloan Kettering (MSK) Cancer Center. An example of one of MSK’s current projects is the development of a mass spec workflow that will provide increased sensitivity beyond conventional measures. The focus is on the measurement of biological sample peptides at the zeptomolar-concentration level. 

Results thus far are promising and although the single-molecule detection level has not been reached, detection is within the “hundreds of molecules” range. The end result is that quantitative measurements of profile pathways within patient samples is becoming more accurate. In particular, it addresses those cancers for which only small patient samples exist and there are not good antibodies to detect.